Alpha Lipoic Acid (ALA)

Alpha Lipoic Acid (ALA) – Antioxidant, Mitochondrial & Metabolic Support

A cofactor for mitochondrial enzymes, ALA protects cells from oxidative stress and supports metabolic pathways. Explore its mechanisms, potential benefits, and clinical evidence in IV therapy.

What the ingredient is

Alpha Lipoic Acid (ALA) is a naturally occurring compound that acts as a potent antioxidant and cofactor for mitochondrial enzyme complexes. It is both water- and fat-soluble, allowing it to work throughout the body in various tissues. ALA cannot be synthesised in sufficient amounts during stress or metabolic imbalance, making supplementation relevant in clinical and wellness settings.

Mechanism of action

ALA functions by:

  • Acting as a cofactor in mitochondrial energy production (pyruvate and alpha-ketoglutarate dehydrogenase complexes)

  • Scavenging reactive oxygen species and regenerating other antioxidants (glutathione, vitamins C and E)

  • Supporting cellular glucose metabolism and insulin sensitivity

  • Modulating redox balance and mitochondrial health

IV administration bypasses digestive limitations and delivers ALA directly for maximal systemic availability.

Physiological roles

Vitamin B12 is required for:

  • Supports cellular energy production and mitochondrial function
  • Acts as a potent antioxidant protecting against oxidative stress
  • Helps regulate glucose metabolism and insulin signalling
  • Supports liver function and detoxification
  • May assist in nerve and cardiovascular health
  • Plays a role in metabolic resilience and ageing pathways

Evidence summary

Research supports ALA’s roles in antioxidant defence, mitochondrial energy production, and metabolic regulation. Clinical studies have shown benefits in diabetic neuropathy, oxidative stress reduction, and insulin sensitivity, though results vary depending on dosage and route of administration. IV therapy provides more immediate systemic availability than oral supplements.

Potential benefits

Enhances cellular energy and mitochondrial efficiency

Protects cells from oxidative damage

Supports metabolic health and insulin sensitivity

May support nerve function and cardiovascular resilience

Contributes to overall cellular vitality and longevity pathways

Safety profile

  • Generally well-tolerated under clinical supervision
  • Mild effects may include headache, nausea, or flushing
  • Caution in individuals with thyroid disorders or hypoglycemia risk
  • IV administration should be monitored for dosing and infusion rate

Interactions

Works synergistically with glutathione, vitamins C & E

May enhance effects of insulin or oral hypoglycemic agents (monitor glucose levels)

Alcohol, high sugar intake, and chronic oxidative stress may reduce endogenous ALA effectiveness

Evidence rating

Moderate to Strong – strong mechanistic and clinical evidence for antioxidant and metabolic support; emerging evidence in longevity and IV applications.

References

  • Shay KP, Moreau RF, Smith EJ, et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta.

  • Biewenga GP, Haenen GR, Bast A. The pharmacology of alpha-lipoic acid. Gen Pharmacol.

  • NIH – Alpha Lipoic Acid Fact Sheet.

  • PubMed clinical studies on ALA in metabolic health and IV therapy.