Magnesium

Magnesium – Muscle Health, Nervous System Calm & Metabolic Energy

As a key cofactor in hundreds of enzymatic reactions, magnesium supports muscle contraction, neurotransmission, and ATP production. Learn how magnesium IV therapy can enhance wellness and recovery.

What the ingredient is

Magnesium is an essential mineral and electrolyte required for over 300 enzymatic reactions in the body. It is involved in energy production, neuromuscular function, and the maintenance of normal physiological processes. Magnesium cannot be synthesized by the body and must be obtained from diet or supplementation.

Mechanism of action

Magnesium acts as:

  • A cofactor in ATP production and mitochondrial function

  • A regulator of muscle contraction and relaxation

  • A modulator of nerve excitability and neurotransmitter release

  • A stabiliser of cell membranes and ion transport, including calcium and potassium

IV magnesium provides rapid replenishment, especially in cases of deficiency, muscle cramps, or acute metabolic needs.

Physiological roles

Vitamin B12 is required for:

  • Supports muscle contraction and relaxation
  • Promotes calm and balanced nervous system activity
  • Essential for ATP synthesis and energy metabolism
  • Maintains electrolyte balance
  • Supports cardiovascular health
  • Assists in bone formation and neuromuscular signalling

Evidence summary

Magnesium deficiency is linked to muscle cramps, fatigue, irritability, and metabolic inefficiency. IV magnesium has been studied in clinical settings for acute deficiency, arrhythmias, pre-eclampsia, and stress-related symptoms. Evidence supports its role in muscle and nerve function, as well as energy production.

Potential benefits

Reduces muscle cramps and tension

Supports nervous system calm and relaxation

Enhances cellular energy and metabolic efficiency

May improve sleep quality and stress resilience

Supports overall cardiovascular and neuromuscular health

Safety profile

  • Generally safe under clinical supervision
  • Possible mild effects: flushing, warmth, or temporary hypotension
  • Caution in renal impairment (risk of magnesium accumulation)
  • High doses can cause diarrhea in oral form; IV dosing should be monitored

Interactions

Magnesium may interact with diuretics or antibiotics (tetracyclines, quinolones)

Works synergistically with potassium and calcium for neuromuscular function

Alcohol and high caffeine intake can reduce magnesium levels

Evidence rating

Strong – well-documented physiological roles, deficiency effects, and clinical applications.

References

  • de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev.

  • NIH Office of Dietary Supplements – Magnesium Fact Sheet.

  • Cuciureanu MD, Vink R. Magnesium and stress. Nutrients.

  • PubMed clinical studies on IV magnesium therapy in neuromuscular and metabolic health.